Current Affairs - Science - Discussion

RAD52 is a DNA repair protein identified by University of Iowa researchers as crucial for cancer cell survival, particularly in cells with BRCA1/2 mutations that impair DNA repair mechanisms. By inhibiting RAD52, researchers can selectively kill cancer cells without heavily affecting normal cells. This approach offers a promising alternative to PARP inhibitors, potentially overcoming drug resistance and reducing side effects associated with traditional treatments like chemotherapy and radiation, thereby opening new therapeutic avenues for cancers with DNA repair deficiencies.