Biochemistry - Carbohydrate - Discussion

Discussion :: Carbohydrate - Section 1 (Q.No.5)


Which of the following compounds is responsible for coordinated regulation of glucose and glycogen metabolism?

[A]. NAD+
[B]. Fructose 2,6 bisphosphate
[C]. Acetyl-CoA
[D]. Fructose 1,6 bisphosphate

Answer: Option B


No answer description available for this question.

Benjamin said: (Feb 2, 2014)  
I have never heard of fructose-2, 6-bisphosphate.

Awar said: (Nov 21, 2014)  
Phosphoglucomutase catalyze conversion of G6p to G1p and require Glucose 1,6 diphosphate and Mg++, so isn't B, its D.

Fatemeh said: (Jun 10, 2015)  
Nope it is indeed b, fructose 6 phosphate is converted into fructose 1, 6 bis phosphate via pfk1.

However, it can also get converted into fructose 2, 6 bisphosphate via pfk2. The product of this reaction is then regulated via hormones insulin and glucagon in which an increase in insulin increases f26bp which stimulates the conversion of f6p to f16bp despite the negative effect (inhibitory) of acetyl co-a accumulation.

Hope this helped!

Abhilash. D said: (Oct 7, 2016)  
Yes, I am familiar only about fructose-6-phosphate and fructose-1, 6-biphosphate.

Abdullahi Ymas said: (Oct 14, 2016)  
Thanks @Fatemeh.

Mollel said: (Nov 29, 2016)  
Not getting this, please explain me.

Apelle Diana said: (Dec 6, 2016)  
NAD is out the list because of its for sucrose.

Aasima said: (Mar 28, 2017)  
I think D should be the answer.

Hanan said: (May 22, 2017)  
Yes, fructose 2, 6 bisphosphate is an activator for glycolysis "pfk1".

Sara said: (Feb 28, 2018)  
I didn't get it, is the answer D or B and why?

Fadel.A said: (Jan 20, 2019)  
Yes, Fructose-2, 6-Bisphosphate activate PFK-1 when insulin levels are high but I don't think that it is implicated in glycogen metabolism.

Nasir Shah said: (Jul 8, 2020)  
Anyone explain the correct answer.

Nasir Shah said: (Jul 8, 2020)  
The hormonal regulation of glycolysis and gluconeogenesis is mediated by fructose 2, 6-bisphosphate.

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