Current Affairs - Awards and Honours - Discussion

The 2025 Nobel Prize in Physiology or Medicine was awarded to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi for their pioneering research on peripheral immune tolerance. Their work identified regulatory T cells (Tregs) and the Foxp3 gene, which are critical in preventing the immune system from attacking the body’s own tissues. These discoveries have transformed immunology and provided new strategies for treating autoimmune diseases, cancer, and transplant rejection. Sakaguchi discovered Tregs, while Brunkow and Ramsdell identified the Foxp3 gene, linking their findings to a deeper understanding of immune system regulation.