Biochemical Engineering - Enzymes and Kinetics - Discussion
Discussion Forum : Enzymes and Kinetics - Section 1 (Q.No. 5)
5.
The rate-determining step of Michaelis Menten kinetics is
Discussion:
2 comments Page 1 of 1.
Akansha pandey said:
2 weeks ago
As we know, S+E---EScomplex---E+P.
Where s is Substrate which is converted into substrate enzyme complex, this step involve 2 things.
A. Forward or association.
B. Reverse or dissociation.
Which further is converted into product with free enzyme, this step is said to be rate determining step (k2).
Where s is Substrate which is converted into substrate enzyme complex, this step involve 2 things.
A. Forward or association.
B. Reverse or dissociation.
Which further is converted into product with free enzyme, this step is said to be rate determining step (k2).
Ngobi john said:
9 years ago
It is always assumed that the rate of formation and dissociation of the enzyme-substrate complex is the same but the fact is that the formation rate is always greater than the dissociation rate* km always greater than kd.
Therefore, it is written to say that the dissociation rate does determine the rate.
Therefore, it is written to say that the dissociation rate does determine the rate.
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