Microbiology - DNA Replication - Discussion
Discussion Forum : DNA Replication - Section 1 (Q.No. 2)
Proofreading activity to maintain the fidelity of DNA synthesis
Discussion:6 comments Page 1 of 1.
Nishtha goyal said: 5 years ago
It means that this process occurs after the formation of the replication fork.
TIMOTHY said: 5 years ago
Once all bases are matched up (A with T, C with G) an enzyme called the exonuclease strips away the primers. The gaps were the primers were are then filled by yet more complementary nucleotides. The new strand is now proofread by DNA polymerase to make sure there is no mistakes in the DNA sequence.
Nanoshe Taye said: 7 years ago
Proofreading exonuclease is capable of degrading DNA starting from 3'DNA end, that is from the growing end of the new DNA.
Noursein said: 8 years ago
I actually didn't understand this question and its answer I urgently need the explanation of this question because I have a biology exam tomorrow.
Mitrabinda said: 1 decade ago
The function of DNA polymerase is to add new nucleotides to the elongation chain, by that time there is a chances of incorporation of wrong base pairs, so the proofreading activity of the enzyme ensures the removal of such wrong bases in both directions & adding correct bases. This occurs by enzymes 3'-5' & 5'-3' exonuclease activity.
Renuka said: 1 decade ago
Proofreading activity to maintain the fidelity of DNA synthesis? How they Work?
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