Biotechnology - Disorders - Discussion

Discussion Forum : Disorders - Section 1 (Q.No. 4)
Which of the modification in hemoglobin is the cause of sickle cell anemia?
A mutation in the beta chain
A deletion in the beta chain
Replacement of the B chain by D chain
None of the above
Answer: Option
No answer description is available. Let's discuss.
1 comments Page 1 of 1.

KRISHNA said:   9 years ago
The sickle-cell disease occurs when the sixth amino acid, glutamic acid, is replaced by valine to change its structure and function; as such, sickle-cell anemia is also known as E6V. Valine is hydrophobic, causing the haemoglobin to collapse on itself occasionally.

The structure is not changed otherwise. When enough haemoglobin collapses on itself the red blood cells become sickle-shaped.

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