Biochemistry - TCA Cycle - Discussion

It's amphibolic.

There are other pathways that originate from the cylcle ie gluconeogenesis transamination heme synthesis and fatty acids synthesis.

It's because many body macromolecules (carbohydrate, lipid, and fatty acid) are produce or manufacture from the reaction that its intermediate pathway of above-mentioned compounds.

The cycle provides intermediates like alpha-Ketoglutaric, citriate,isocitric and oxaloacetate. The oxaloacetate produced can then be channeled to gluconeogenesis pathway for formation of glucose.

There are certain reactions that can feed intermediates into the TCA cycle, these reactions are called Anaplerotic Reactions. As these intermediates are also part of other systems, it can suggest that process of TCA is flexible and will adapt to accommodate different conditions of the cell. e.g. when there is sufficient energy, TCA is less likely to take place.