Biochemistry - TCA Cycle - Discussion

Discussion Forum : TCA Cycle - Section 1 (Q.No. 2)
Why is the TCA cycle the central pathway of metabolism of the cell?
It occurs in the center of the cell
Its intermediates are commonly used by other metabolic reactions
All other metabolic pathways depend upon it
None of the above
Answer: Option
No answer description is available. Let's discuss.
4 comments Page 1 of 1.

Nath said:   4 years ago
It's amphibolic.

There are other pathways that originate from the cylcle ie gluconeogenesis transamination heme synthesis and fatty acids synthesis.

Sulyman Ajao said:   6 years ago
It's because many body macromolecules (carbohydrate, lipid, and fatty acid) are produce or manufacture from the reaction that its intermediate pathway of above-mentioned compounds.

Kevin Tony said:   9 years ago
The cycle provides intermediates like alpha-Ketoglutaric, citriate,isocitric and oxaloacetate. The oxaloacetate produced can then be channeled to gluconeogenesis pathway for formation of glucose.

Vin said:   9 years ago
There are certain reactions that can feed intermediates into the TCA cycle, these reactions are called Anaplerotic Reactions. As these intermediates are also part of other systems, it can suggest that process of TCA is flexible and will adapt to accommodate different conditions of the cell. e.g. when there is sufficient energy, TCA is less likely to take place.

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