Biochemistry - TCA Cycle - Discussion
Discussion Forum : TCA Cycle - Section 1 (Q.No. 23)
23.
How many ATPs are produced during citric acid cycle?
Discussion:
10 comments Page 1 of 1.
Kennedy Moyo said:
2 years ago
The answer is 10.
TCA has eight steps.
4 of these steps are oxidative.
Which are steps 3,4,6 & 8.
They are 1 ATP that is produced at substrate level phosphorylation that is synthesized to become 1 just like that but in the 4 oxidative steps 1 step Carries FAD which translates in a 1.5 atp, then the remaining 3 NADH accounts for 2.5 each.
If you add rightfully you get 10 atp Molecules per cycle.
TCA has eight steps.
4 of these steps are oxidative.
Which are steps 3,4,6 & 8.
They are 1 ATP that is produced at substrate level phosphorylation that is synthesized to become 1 just like that but in the 4 oxidative steps 1 step Carries FAD which translates in a 1.5 atp, then the remaining 3 NADH accounts for 2.5 each.
If you add rightfully you get 10 atp Molecules per cycle.
(1)
Sherif wael said:
7 years ago
1 GTP 3 NADH and 1 FADH2 are also produced.
1 NADH= 2.5ATP and 1 FADH2= 1.5 ATP.
1 NADH= 2.5ATP and 1 FADH2= 1.5 ATP.
Ebisa said:
9 years ago
I think it must be 10 because in TCA the output of one glucose molecule is: 2ATP, 6NADh, 2FADH2.
Mah479 said:
9 years ago
I think it should be 10.
(1)
Awesome Prince said:
9 years ago
10 ATPs are produced in the TCA cycle, 2 NADH and 1 FADH2 are also produced.
1 NADH= 2.5ATP and 1 FADH2= 1.5 ATP,
Making the total number of ATPs produced 10.
1 NADH= 2.5ATP and 1 FADH2= 1.5 ATP,
Making the total number of ATPs produced 10.
Rathi said:
10 years ago
The main purpose of the citric acid cycle is not just the disposition of the carbon and hydrogens of all those compounds that can generate acetyl-CoA or any of the cycle members, but is the conversion of potential chemical energy into metabolic energy in the form of ATP. A grand total of 12 ATP molecules is formed during complete oxidation of one mole of acetyl-CoA, i.e., during one turn of the citric acid cycle.
(However, a total of 15 ATP moles is formed when we start with the oxidation of 1 mole of pyruvate. This corresponds to a total of 38 ATP moles for the oxidation of 1 mole of glucose).
Out of these 12 ATP molecules, only one ATP is produced directly at the level of the cycle itself (i.e., at the substrate level) in the reaction catalyzed by succinyl-CoA synthase. And the rest 11 ATP molecules are generated as a consequence of oxidation-reduction reactions of the cycle. Three molecules of NADH and one mole of FADH2 are produced in one turn of the cycle. The oxidation of one mole of NADH by O2 results in the formation of 3 ATP molecules from ADP plus Pi, thus producing a total of 9 ATP molecules. However, the oxidation of FADH2 by O2 produces 2 molecules of ATP, rather than 3. Thus, a total of 12 ATP moles are generated utilizing 12 ADP and 12 Pi.
(However, a total of 15 ATP moles is formed when we start with the oxidation of 1 mole of pyruvate. This corresponds to a total of 38 ATP moles for the oxidation of 1 mole of glucose).
Out of these 12 ATP molecules, only one ATP is produced directly at the level of the cycle itself (i.e., at the substrate level) in the reaction catalyzed by succinyl-CoA synthase. And the rest 11 ATP molecules are generated as a consequence of oxidation-reduction reactions of the cycle. Three molecules of NADH and one mole of FADH2 are produced in one turn of the cycle. The oxidation of one mole of NADH by O2 results in the formation of 3 ATP molecules from ADP plus Pi, thus producing a total of 9 ATP molecules. However, the oxidation of FADH2 by O2 produces 2 molecules of ATP, rather than 3. Thus, a total of 12 ATP moles are generated utilizing 12 ADP and 12 Pi.
Nikos said:
1 decade ago
It has changed. Each of NADH produces 2.5 ATP and FADH2 produces 1.5 ATP.
Liji Nair said:
1 decade ago
According to new conventional method one NADH = 2.5 ATP and FADH2 = 1.5 ATP. So TCA cycle results in formation of 10 ATP per cycle.
Sofie said:
1 decade ago
From one Acetyl CoA it is produced one ATP, though there's 3 NADH and 1 FADH2 it means that maybe these produce that amount of ATP? But oxidative phosphorylation is not involved in the citric acid cycle.
Michael said:
1 decade ago
Only two one molecule of ATP is produced during the TCA cycle. The answers seem to suggest that ATP produced as a result of oxidative phosphorylation using reducing equivalents from the TCA cycle are to be included in the count.
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