Biochemistry - Carbohydrate - Discussion

Discussion Forum : Carbohydrate - Section 1 (Q.No. 24)
24.
Pyruvate is initially converted to which of the following in the gluconeogenesis?
Glycerol
Phosphoenol pyruvate
Oxaloacetate
Acetyl CoA
Answer: Option
Explanation:
No answer description is available. Let's discuss.
Discussion:
3 comments Page 1 of 1.

Assu said:   5 years ago
The first Step of Gluconeogenesis is Conversion of pyruvate to Phosphoenol Pyruvate PEP.

This requires the action of 2 Mitochondrial Enzymes:

The first is an ATP requiring reaction catalysed by pyruvate Carboxylase PC.
Pyruvate is carboxylated to form Oxalacetate OAA. .

The second Enzyme in the conversion of pyruvate to PEP is: PEP carboxykinase PEPCK.

PEPCK requires GTP in the decarboxylation of OAA to yield to PEP.

Awab Ahsn said:   5 years ago
In the first step of gluconeogenesis, pyruvate is converted into phosphoenol pyruvate then why the correct option is C (Oxaloacetate)?

Shakil said:   9 years ago
Why its answer is oxaloacetate, not Acetyl CoA?

Please discuss accordingly with logical reasons.
(1)

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