Biochemistry - Nucleic Acids - Discussion

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"The secret to creativity is knowing how to hide your sources."
- Albert Einstein

Because DNA is a highly charged polyanion, its stability to heat denaturation

[A]. does not depend on hydrophobic interactions
[B]. increases with increasing salt
[C]. is independent of G - C content
[D]. decreases with increasing salt

Answer: Option


No answer description available for this question.

Deus Mselle said: (Thu, Nov 8, 2012 12:34:49 PM)    
How does the increase in salt concentration increase the stability and which types of salts?

Bernadette said: (Wed, Jan 9, 2013 02:34:47 PM)    
Acidic salts increase the stability of DNA because they are made of bases purines and pyrimidines.

Cookey said: (Tue, Nov 26, 2013 08:03:13 PM)    
Yeah that's absolutely true, acidic salts like NaHSO4.

Faisal Biochemist said: (Sat, Jun 7, 2014 05:24:45 PM)    
As high salt concentrations mask the destabilising charge repulsion between the two negatively charged phosphodiester backbones. DNA duplex stability therefore increases with increasing salt concentration.

Vinayak said: (Tue, Aug 19, 2014 03:17:38 PM)    
Increase in salt concentration mask the charge on both strands of DNA. Thus making them very stable and the resultant repulsion force will be minimized. As a result the stability of DNA increases with increase in salt concentration and require higher temperature than in absence of salt.

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